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1

The crystal structure of the proprotein processing proteinase furin explains its stringent specificity

Henrich, Stefan, Cameron, Angus, Bourenkov, Gleb P, Kiefersauer, Reiner, Huber, Robert, Lindberg, Iris, Bode, Wolfram, Than, Manuel E

Journal:

Natural Structural Biology

Year:

2003

Language:

english

File:

PDF, 1.72 MB

english, 2003

2

Production of bioactive peptides in an in vitro system

Akihiko Ozawa, Yang Cai, Iris Lindberg

Journal:

Analytical Biochemistry

Year:

2007

Language:

english

File:

PDF, 379 KB

english, 2007

3

New furin inhibitors based on weakly basic amidinohydrazones

Frank Sielaff, Manuel E. Than, Dorian Bevec, Iris Lindberg, Torsten Steinmetzer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 654 KB

english, 2011

4

Mini-RIA: adaptation of conventional 125I-labeled radioimmunoassay to a 96-tube format

Virginie Laurent, Iris Lindberg

Journal:

Analytical Biochemistry

Year:

2002

Language:

english

File:

PDF, 177 KB

english, 2002

5

Role of PC2 in Proenkephalin Processing: Antisense and Overexpression Studies

Karla Johanning, John P. Mathis, Iris Lindberg

Journal:

Journal of Neurochemistry

Year:

1996

Language:

english

File:

PDF, 1.04 MB

english, 1996

6

The Role of the 7B2 CT Peptide in the Inhibition of Prohormone Convertase 2 in Endocrine Cell Lines

Yolanda Fortenberry, June Liu, Iris Lindberg

Journal:

Journal of Neurochemistry

Year:

1999

Language:

english

File:

PDF, 151 KB

english, 1999

7

Increased synthesis but decreased processing of neuronal proCCK in prohormone convertase 2 and 7B2 knockout animals

Jens F. Rehfeld, Iris Lindberg, Lennart Friis-Hansen

Journal:

Journal of Neurochemistry

Year:

2002

Language:

english

File:

PDF, 385 KB

english, 2002

8

Cleavage of recombinant proenkephalin and blockade mutants by prohormone convertases 1 and 2: an in vitro specificity study

Juan R. Peinado, Hong Li, Karla Johanning, Iris Lindberg

Journal:

Journal of Neurochemistry

Year:

2003

Language:

english

File:

PDF, 784 KB

english, 2003

9

Overexpression ofScg5increases enzymatic activity of PCSK2 and is inversely correlated with body weight in congenic mice

Charles R Farber, James Chitwood, Sang-Nam Lee, Ricardo A Verdugo, Alma Islas-Trejo, Gonzalo Rincon, Iris Lindberg, Juan F Medrano

Journal:

Year:

2008

Language:

english

File:

PDF, 430 KB

english, 2008

10

Characterization of Enkephalin Release from Rat Striatum

Iris Lindberg, June L. Dahl

Journal:

Journal of Neurochemistry

Year:

1981

Language:

english

File:

PDF, 534 KB

english, 1981

11

Characterization of Proenkephalin-Cleaving Proteinases in Bovine Adrenal Chromaffin Granules Using [35S]Proenkephalin Copolymerized into Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis

Steven F. Roberts, Joseph W. Irvine, Iris Lindberg

Journal:

Journal of Neurochemistry

Year:

1992

Language:

english

File:

PDF, 1.18 MB

english, 1992

12

Proteolytic Processing of Chromogranins Is Modified in Brains of Transgenic Mice

ANDREA LASLOP, ALEXANDRA BECKER, IRIS LINDBERG, REINER FISCHER-COLBRIE

Journal:

Annals of the New York Academy of Sciences

Year:

2002

File:

PDF, 1.41 MB

2002

13

Proenkephalin transgenic mice: A short promoter confers high testis expression and reduced fertility

Bruce F. O'Hara, David M. Donovan, Iris Lindberg, Michael T. Brannock, Deborah D. Ricker, Christopher A. Moffatt, Brenda A. Klaunberg, Charles Schindler, Thomas S. K. Chang, Randy J. Nelson, George R.

Journal:

Molecular Reproduction and Development

Year:

1994

Language:

english

File:

PDF, 1.14 MB

english, 1994

14

Deorphanization of Novel Peptides and Their Receptors

Akihiko Ozawa, Iris Lindberg, Bryan Roth, Wesley K. Kroeze

Journal:

The AAPS Journal

Year:

2010

Language:

english

File:

PDF, 152 KB

english, 2010

15

Distribution and characterization of the opioid octapeptide met5-enkephalin-arg6-gly7-leu8in the gastrointestinal tract of the rat

Yen-Nung Wang, Iris Lindberg

Journal:

Cell and Tissue Research

Year:

1986

Language:

english

File:

PDF, 2.14 MB

english, 1986

16

Prohormone convertases and their binding proteins: New roles for binding proteins

Journal:

Regulatory Peptides

Year:

2012

Language:

english

File:

PDF, 45 KB

english, 2012

17

Purification and Enzymatic Characterization of Recombinant Prohormone Convertase 2: Stabilization of Activity by 21 kDa 7B2

Nazarius S. Lamango, Xiaorong Zhu, Iris Lindberg

Journal:

Archives of Biochemistry and Biophysics

Year:

1996

Language:

english

File:

PDF, 321 KB

english, 1996

18

The Proteolytic Maturation of Prohormone Convertase 2 (PC2) is a pH-Driven Process

Nazarius S. Lamango, Ekaterina Apletalina, June Liu, Iris Lindberg

Journal:

Archives of Biochemistry and Biophysics

Year:

1999

Language:

english

File:

PDF, 171 KB

english, 1999

19

Structure–Function Analysis of the 7B2 CT Peptide

Ekaterina V. Apletalina, Maria A. Juliano, Luiz Juliano, Iris Lindberg

Journal:

Biochemical and Biophysical Research Communications

Year:

2000

Language:

english

File:

PDF, 38 KB

english, 2000

20

Fluorometric assay of a calcium-dependent, paired-basic processing endopeptidase present in insulinoma granules

Iris Lindberg, Beth Lincoln, Christopher J. Rhodes

Journal:

Biochemical and Biophysical Research Communications

Year:

1992

Language:

english

File:

PDF, 482 KB

english, 1992

21

A study of human furin specificity using synthetic peptides derived from natural substrates, and effects of potassium ions

Mario A. Izidoro, Iuri E. Gouvea, Jorge A.N. Santos, Diego M. Assis, Vitor Oliveira, Wagner A.S. Judice, Maria A. Juliano, Iris Lindberg, Luiz Juliano

Journal:

Archives of Biochemistry and Biophysics

Year:

2009

Language:

english

File:

PDF, 593 KB

english, 2009

22

Cross-inhibition between furin and lethal factor inhibitors

Juan R. Peinado, Magdalena M. Kacprzak, Stephen H. Leppla, Iris Lindberg

Journal:

Biochemical and Biophysical Research Communications

Year:

2004

Language:

english

File:

PDF, 367 KB

english, 2004

23

Processing and trafficking of a prohormone convertase 2 active site mutant

Sang-Nam Lee, Magdalena M. Kacprzak, Robert Day, Iris Lindberg

Journal:

Biochemical and Biophysical Research Communications

Year:

2007

Language:

english

File:

PDF, 199 KB

english, 2007

24

Proprotein Convertase Models based on the Crystal Structures of Furin and Kexin: Explanation of their Specificity

Stefan Henrich, Iris Lindberg, Wolfram Bode, Manuel E. Than

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 1.24 MB

english, 2005

25

The SAAS granin exhibits structural and functional homology to 7B2 and contains a highly potent hexapeptide inhibitor of PC1

Angus Cameron, Yolanda Fortenberry, Iris Lindberg

Journal:

Year:

2000

Language:

english

File:

PDF, 114 KB

english, 2000

26

Progastrin processing differs in 7B2 and PC2 knockout animals: a role for 7B2 independent of action on PC2

Jens F. Rehfeld, Iris Lindberg, Lennart Friis-Hansen

Journal:

Year:

2002

Language:

english

File:

PDF, 126 KB

english, 2002

27

The Neuroendocrine Protein 7B2 Is Required for Peptide Hormone Processing In Vivo and Provides a Novel Mechanism for Pituitary Cushing’s Disease

Christoph H Westphal, Laurent Muller, An Zhou, Xiaorong Zhu, Susan Bonner-Weir, Morris Schambelan, Donald F Steiner, Iris Lindberg, Philip Leder

Journal:

Year:

1999

Language:

english

File:

PDF, 657 KB

english, 1999

28

Prohormone convertase 2 enzymatic activity and its regulation in neuro-endocrine cells and tissues

Qiao-Ling Li, Syed Naqvi, Xiaoxiong Shen, Yan-Jun Liu, Iris Lindberg, Theodore C Friedman

Journal:

Regulatory Peptides

Year:

2003

Language:

english

File:

PDF, 266 KB

english, 2003

29

Hexa-D-arginine treatment increases 7B2•PC2 activity in hyp -mouse osteoblasts and rescues the HYP phenotype

Yuan, Baozhi, Feng, Jian Q, Bowman, Stephen, Liu, Ying, Blank, Robert D, Lindberg, Iris, Drezner, Marc K

Journal:

Journal of Bone and Mineral Research

Year:

2013

Language:

english

File:

PDF, 2.51 MB

english, 2013

30

Regional distribution of enkephalin in bovine brain

Iris Lindberg, Sandra J. Smythe, June L. Dahl

Journal:

Year:

1979

Language:

english

File:

PDF, 303 KB

english, 1979

31

Multiple immunoreactive forms of met- and leu-enkephalin in fetal and neonatal rat brain and in rat gut

June L. Dahl, Miles L. Epstein, Barbara L. Silva, Iris Lindberg

Journal:

Year:

1982

Language:

english

File:

PDF, 206 KB

english, 1982

32

On the evolution of proenkephalin

Journal:

Trends in Pharmacological Sciences

Year:

1986

Language:

english

File:

PDF, 355 KB

english, 1986

33

66 Diagnosis of a Mysterious Case of Proprotein Convertase (PC1/3) Deficiency in a Patient With Malabsorptive Diarrhea With Next Generation Sequencing

Sergio Solorzano, Lindsay A. Pickett, Lindberg Iris, Jiafang Wang, Galen Cortina, Anna Pawlikowska-Haddal, Howard Baron, Robert Venick, Stanley Nelson, Martin G. Martin, Michael Yourshaw

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 66 KB

english, 2012

34

Peptide Biosynthesis: Prohormone Convertases 1/3 and 2

Hoshino, Akina, Lindberg, Iris

Journal:

Colloquium Series on Neuropeptides

Year:

2012

Language:

english

File:

PDF, 1.42 MB

english, 2012

35

7B2 Prevents Unfolding and Aggregation of Prohormone Convertase 2

Lee, Sang-Nam, Lindberg, Iris

Journal:

Year:

2008

Language:

english

File:

PDF, 513 KB

english, 2008

36

Effects of magnesium ions on recombinant human furin: selective activation of hydrolytic activity upon substrates derived from virus envelope glycoprotein

Izidoro, Mario A., Assis, Diego M., Oliveira, Vitor, Santos, Jorge A.N., Juliano, Maria A., Lindberg, Iris, Juliano, Luiz

Journal:

Biological Chemistry

Year:

2010

Language:

english

File:

PDF, 232 KB

english, 2010

37

Appendix

Epstein, Miles L., Lindberg, Iris, Dahl, June L.

Journal:

Seminars in Colon and Rectal Surgery

Year:

2006

Language:

english

File:

PDF, 22 KB

english, 2006

38

Lord Salisbury as a Man of Science

Epstein, Miles L., Lindberg, Iris, Dahl, June L.

Journal:

Year:

1903

Language:

english

File:

PDF, 316 KB

english, 1903

39

Development of enkephalinergic neurons in the gut of the chick

Epstein, Miles L., Lindberg, Iris, Dahl, June L.

Journal:

Year:

1981

Language:

english

File:

PDF, 503 KB

english, 1981

40

Blockade of islet amyloid polypeptide fibrillation and cytotoxicity by the secretory chaperones 7B2 and proSAAS

Peinado, Juan R., Sami, Furqan, Rajpurohit, Nina, Lindberg, Iris

Journal:

Year:

2013

Language:

english

File:

PDF, 721 KB

english, 2013

41

Women's experiences after an induced second trimester abortion

Mukkavaara, Iris, Öhrling, Kerstin, Lindberg, Inger

Journal:

Year:

2012

Language:

english

File:

PDF, 157 KB

english, 2012

42

Congenital Proprotein Convertase 1/3 Deficiency Causes Malabsorptive Diarrhea and Other Endocrinopathies in a Pediatric Cohort

Martín, Martín G., Lindberg, Iris, Solorzano–Vargas, R. Sergio, Wang, Jiafang, Avitzur, Yaron, Bandsma, Robert, Sokollik, Christiane, Lawrence, Sarah, Pickett, Lindsay A., Chen, Zijun, Egritas, Odul,

Journal:

Gastroenterology

Year:

2013

Language:

english

File:

PDF, 1.58 MB

english, 2013

43

Biochemical and Cell Biological Properties of the Human Prohormone Convertase 1/3 Ser357Gly Mutation: A PC1/3 Hypermorph

Blanco, Elias H., Peinado, Juan R., Martín, Martín G., Lindberg, Iris

Journal:

Year:

2014

Language:

english

File:

PDF, 2.41 MB

english, 2014

44

Mechanism of the Facilitation of PC2 Maturation by 7B2: Involvement in ProPC2 Transport and Activation but Not Folding

Laurent Muller, Xiaorong Zhu and Iris Lindberg

Journal:

The Journal of Cell Biology

Year:

1997

Language:

english

File:

PDF, 1.31 MB

english, 1997

45

7B2 Facilitates the Maturation of proPC2 in Neuroendocrine Cells and Is Required for the Expression of Enzymatic Activity

Xiaorong Zhu and Iris Lindberg

Journal:

The Journal of Cell Biology

Year:

1995

Language:

english

File:

PDF, 1.42 MB

english, 1995

46

A novel function for proSAAS as an amyloid anti-aggregant in Alzheimer's disease

Hoshino, Akina, Helwig, Michael, Rezaei, Sina, Berridge, Casey, Eriksen, Jason L., Lindberg, Iris

Journal:

Journal of Neurochemistry

Year:

2014

Language:

english

File:

PDF, 718 KB

english, 2014

47

Enzymic characterization of immunopurified prohormone convertase 2: Potent inhibition by a 7B2 peptide fragment. [Erratum to document cited in CA122:259381]

Lindberg, Iris, van den Hurk, Wilhelmina H., Bui, Chau, Batie, Christopher J.

Journal:

Year:

1995

Language:

english

File:

PDF, 54 KB

english, 1995

48

Enzymic characterization of immunopurified prohormone convertase 2: Potent inhibition by a 7B2 peptide fragment

Lindberg, Iris, van den Hurk, Wilhelmina H., Bui, Chau, Batie, Christopher J.

Journal:

Year:

1995

Language:

english

File:

PDF, 1.74 MB

english, 1995

49

Structural Studies of a Neuropeptide Precursor Protein with an RGD Proteolytic Site †

Zachariah, Cherian, Cameron, Angus, Lindberg, Iris, Kao, K. J., Beinfeld, Margery C., Edison, Arthur S.

Journal:

Year:

2001

Language:

english

File:

PDF, 501 KB

english, 2001

50

Potent Inhibitors of Furin and Furin-like Proprotein Convertases Containing Decarboxylated P1 Arginine Mimetics

Becker, Gero L., Sielaff, Frank, Than, Manuel E., Lindberg, Iris, Routhier, Sophie, Day, Robert, Lu, Yinghui, Garten, Wolfgang, Steinmetzer, Torsten

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 4.66 MB

english, 2010